Ok.
My original issue was the BSoD upon starting the game. None of the intro movies loaded, it simply stayed black leaving the fed cursor. I was still able to open the console to generate a report however.
After kirk2164's suggestion of altering the _init_.py in the AdvancedTechnologies/data folder, the game started normally. However upon selecting Quickbattle, the loading screen would pop up for about a second. During that brief moment the various ship sounds could be heard, like the engine hum and a few beeps. It would then kick me straight back to the desktop, no error messages or anything.
This happens even when the mutators are toggled off.