The Orville is hardly "comedy centric" thou. The early promos were very misleading, by focusing solely on the comedic elements of the show, which as of last episode (Episode 4) are a lot less numerous than they were in the pilot episode. Past 2 episodes have been very... "Trek-like" with Episode 4 bearing some similarity to the TOS episode 'For the World is Hollow and I have Touched the Sky'.
Sure, the show still uses comedy and current-day "gags" on occasion, but there is considerable seriousness to each episode as well, handled in a far more believable way than most instances of Trek. All and all, an enjoyable show so far. And if anyone doubts Seth MacFarlane's ability to be "dramatic", needs to watch especially Episodes 3 and 4.
The Orville is neither a Comedy or Drama series. It's a "Dramedy" more in line with shows like M*A*S*H and Stargate, and a far cry from Seth's other comedic works like Family Guy or American Dad.