Nope, no dice.
If I disconnect the other 2 monitors (only using the 2560x1440 native one that's in front of me), same result.
No mouse pointer, so I can't play the game.
Also, the game locks up if I try to do anything (start a quick battle, adjust settings, etc.).
Same deal, fullscreen or windowed mode.
Even if my Windows desktop is 1920x1080, and the game is supposed to be running at 1920x1080, the game window looks zoomed in to the upper left, so the right and bottom-most menu items are cut off.