Well, this is officially the most attended Trek movie domestically. They say its very likely that it will gross 250 million in the US and that it will make 370-380 worldwide.
http://trekmovie.com/2009/06/20/star-trek-passes-tmp-to-beomce-most-attended-film-in-franchise-domestic/Here are more recent numbers.
http://trekmovie.com/2009/06/22/st09-tidbits-weekend-box-office-interview-bits-from-pine-abrams-nimoy-kurtzman/Orci and Kurtzman say the next two movies could be linked...they could be not. That and ofcourse more about the Khan possibility.
"We literally have not started to break story yet. We are just getting through all this ['Transformers' press] and then figuring out what we are doing next. We have had one ten-minute conversation the other day, but that is it."
But apparently they did cover some ground in that 10 minute convo. Collider also talked to the pair at the event and they said Paramount wanted to make the film "as soon as possible" and they were debating the two kinds of possible plots, specifically Orci stated
"exploration sci-fi plot where the unknown and nature itself is somehow an adversary or the villain model. That?s an active discussion we?re having right now. In terms of thinking about more than one movie, we want the movie to be self-contained in a way, but we?re discussing the idea of having a couple of threads where if the second movie works, you could pick up into a cohesive whole."
Specifically Orci cited the example of Spock giving his katra to McCoy in Star Trek II and how that paid off in Star Trek III.
Orci also talked to our friend Ed Gross who has an audio clip up at ComicBookMovie, who asked him specifically about Khan, with Bob noting it is "obviously tempting" to use Khan again, and noted what a great villain he is, in the same pantheon as Darth Vader. However, Bob also noted that there are risks of going back to Khan saying they are "of two minds" and asked "why take the chance?"
http://trekmovie.com/2009/06/20/orci-kurtzman-talk-star-trek-sequel-and-the-one-after-that-too/