I have a bunch of games running & no issues. Most all of them modded. Maybe the plethora of modding tools is causing issues, no idea. Mass Effect (vanilla), Dragon Age, Skyrim (modded), Fallout4 (modded), Far Cry 4 (modded), GTA:V (modded), Oblivion (heavily modded), BF Bad Co 2 (vanilla), Spore and so on..
Verified my disc is good. Installed on an older machine running Vista of all things and no problems.